Evidence of Efficacy

We have been developing, refining, and testing MF-PEP and IF-PEP for over 20 years. Our research group at The Ohio State University has completed two randomized clinical trials (RCTs) and several open-label trials for MF-PEP and three RCTs for IF-PEP.


  • MF-PEP–Funded by the National Institute of Mental Health (NIMH), the Ohio Department of Mental Health (ODMH) and the OSU Center for Clinical and Translational Research
    • High degree of consumer satisfaction (parents and children)
    • Decreased mood severity
    • Decreased behavioral symptoms
    • Improved family interactions
    • Improved access to care
    • High consumer and therapist satisfaction
    • Transportability into the community works
    • Adaptations for MF-PEP with adolescents work
  • IF-PEP–Funded by NIMH and ODMH
    • Two trials of IF-PEP and omega3 fatty acids demonstrate that combination treatment is beneficial in improving mood in youth aged 7-14 with depression and bipolar disorder-not otherwise specified/cyclothymic disorder
    • High degree of consumer satisfaction
    • Suggestion of decreased mood severity (need to test in a larger sample)
    • Improved family interactions
    • Suggestion of improved access to care (need to test in a larger sample)


MF-PEP for Autism Spectrum Disorders: Children with Autism Spectrum Disorder (ASD) frequently have emotional and behavioral dysregulation that appears similar to what we see in children with primary mood disorders. Thus, we adapted our MF-PEP treatment manual and workbooks for children with primary diagnoses of ASD. We began a pilot clinical trial of this adapation in 2010, we have several papers in submission from this work. Funded in part by the OSU-NCH Jeffrey Fellowship and a Canadian Institute of Health Research fellowship.

IF-PEP via Tele-Health: As not all children have geographic access to trained clinicians, we have also started a tele-health project, in which we are determining whether a video-conferencing version of IF-PEP will be effective in treating rural children with mood disorders. Funded by the Wichita Council for Graduate Medical Education and Kansas Bioscience Authority.


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